Systemic Degos disease affects a number of body systems:
- skin - pink or red papules (solid raised lesions) primarily on the trunk (mid part of body) and limbs, which heal to leave white scars
- gastrointestinal - abdominal pain, nausea, vomiting, diarrhoea or constipation and, in the later stages, intestinal perforation (small holes appearing in the intestine) and haemorrhage (bleeding from the intestine) may occur
- neurological - manifestations involve the peripheral (systems around the edge of the body) and central nervous systems leading to headaches, dizziness, seizures, hemiplegia (total or partial paralysis of one side of the body), aphasia, paraplegia (paralysis of the lower half of the body), and gaze palsy (partial or complete inability to move the eyes to all directions of gaze)
- ocular (eyes) - ptosis (drooping of the upper eyelid), optic neuritis (inflammation of optic nerves), diplopia (double vision) and visual field defects may occur.
Benign Degos disease usually only produces the typical skin lesions of the condition.