Characteristics include macrocephaly (large head) with accelerated bone development. Children may have delayed development and language problems. In addition, the faces of children with Sotos syndrome may appear similar, including widely spaced eyes, a prominent jaw and high-arched palate (roof of the mouth). Some children will have normal intelligence; however, some may have a mild form of learning disability. Children with Sotos syndrome may be clumsy or ataxic (unsteady).
Growth rate of children with Sotos syndrome usually slows at four to five years of age. Adults are usually a similar height to adults without the syndrome. Weaver syndrome is a condition characterised by accelerated growth, mild hypotonia (low muscle tone), loose skin, thin hair and camptodactyly (permanent immobility of a flexed finger joint). In the first years of life, Sotos syndrome may be misdiagnosed as Weaver syndrome.
Some people with Sotos syndrome also have behavioural problems. Frequent behavioural issues include attention deficit hyperactivity disorder (ADHD), phobias, obsessions and compulsions, tantrums and impulsive behaviours.