The symptoms of ACC are best described under two headings: syndromic (those that are associated with a known syndrome), and nonsyndromic, agenesis of the corpus callosum that is not part of a known syndrome.
Non-syndromic ACC is common and affected patients usually have a large head, seizures and developmental delay. Hypertelorism (widely spaced eyes) also occur in many people with the condition. Seizures may be difficult to control. Hydrocephalus can also occur.
Many neurological syndromes also include ACC. All of these have additional brain malformations and affected individuals are usually severely affected often displaying typical facial features and global developmental delay. This is often associated with other midline cerebral and cranial abnormalities such as septo-optic dysplasia. ACC is sometimes associated with abnormal development of the pituitary gland. Because of this, fits are sometimes due to hypoglycaemia (low levels of growth hormone and cortisol) as well as due to structural brain abnormality.