AHO with pseudohypoparathyroidism (PHP) In addition to AHO, in PHP the body is unable to respond to various hormones. One such hormone is parathyroid hormone (PTH), which maintains levels of calcium and phosphate in the blood. In PHP, parathyroid hormone is produced in normal or increased amounts by the parathyroid glands and released into the blood. However, the body is resistant to its effects causing hypocalcaemia (low calcium levels), and hyperphosphatemia (high phosphate levels). Signs of hypocalcaemia include tingling in the fingers, muscle cramps, possible seizures (fits) and, in the longer term, cataracts. Hypocalcaemia typically begins in mid-childhood. Individuals with PHP are often resistant to thyroid stimulating hormone (TSH), which makes the thyroid gland produce thyroid hormone. The effects of lack of thyroid hormone are a tendency to gain weight easily and to feel the cold, dry skin and hair, and a lack of energy.
Pseudo-pseudohypoparathyroidism (PPHP) People with this condition have the physical characteristics of AHO but they do not have any hormone abnormalities (that is, they just have AHO). The complicated name arose for historical reasons.