There is a wide variation in the degree of problems seen in this condition. Children with Wolf-Hirschhorn usually have:
- a low birth weight
- slow weight gain
- difficulty with feeding
- delayed development (see entry Global Developmental Delay)
- microcephaly (small head size)
Affected individuals tend to have similar facial features. These may include a broad bridge to the nose, wide-spaced eyes and a small chin.
Learning difficulties (see entry Learning Disability) are variable and can be moderate to severe.
Children with Wolf-Hirschhorn syndrome may be born with some other congenital problems. The most commonly recognised include: cleft lip and/or palate, congenital heart disease, (see entry Heart Defects), kidney problems (see entry Kidney disease), eye anomalies such as coloboma, undescended testes and hypospadias.