What are the symptoms? In SCN frequent infections can develop very rapidly due to the impaired ability of children to combat them. Infections include: mouth ulcers and gingivitis (inflammation of the gums);sore throatchest infectionsdiarrhoeaburning sensation when urinatingunusual redness, pain, or swelling around a woundhigh fevers and chillsexhaustion and lethargy. What are the causes? The cause of SCN differs according to the specific type and can be hereditary, autoimmune (in which the body destroys its own neutrophils), related to bone marrow production or idiopathic (of unknown cause). How is it diagnosed? Diagnosis of the different types of SCN is made by blood tests and bone marrow aspiration and biopsy (examination). How is it treated? Granulocyte Colony Stimulating Factor (G-CSF) is used in the management of SCN and can significantly improve the quality of life by stimulating the bone marrow to produce neutrophils to fight infections. G-CSFs are given by an injection just under the skin using a very small needle. To make this less painful, a local-anaesthetic cream can be applied to the site half an hour before the injection is due. Prophylactic antibiotics may be given in addition, or are often effective alone for less severely affected individuals. Inheritance patterns and prenatal diagnosis Inheritance patternsCongenital neutropenia is typically sporadic but autosomal dominant and recessive cases are also described. Cyclical neutropenia is typically autosomal dominant but can be sporadic (with no other affected family members). Prenatal diagnosisThis is theoretically possible if a causative mutation is identified. It is usual to find a mutation in around 60 to 70 per cent of cases of severe congenital neutropenia and cyclical neutropenia. Is there support? There is no support group for Neutropenia (Severe Chronic) in the UK. Families can use Contact’s freephone helpline for advice, information and, where possible, links to other families. To meet other families with disabled children, join Contact’s closed (private) Facebook group.