Peters Anomaly/Peters Plus syndrome

Also known as: Anterior Chamber Cleavage syndrome; Peters Anomaly; Peters Plus syndrome


In Peters anomaly, the central part of the cornea (the transparent window of the eye) is hazy and white in one or both eyes. If both eyes are affected, the child will not be able to clearly see what an object is. It can be associated with other eye problems that contribute to reduced vision including glaucoma, nystagmus (involuntary eye movement), microphthalmia (small eye), and cataracts. Peters anomaly can be associated with abnormalities of the heart or central nervous system and some children have developmental delay. Peters Plus syndrome occurs when Peters anomaly is associated with short-limb dwarfism and learning disability. Peters anomaly can be the result of an error in one or more genes or possibly environmental influences on the developing eye. A diagnosis is made by examination by an ophthalmologist. If Peters anomaly affects both eyes cornea transplant surgery may be carried out. Spectacles with dark lenses to help with sun glare and contact lenses improve comfort of eyesight. Most cases occur sporadically (with no family history) but it can be inherited. Affected families should be referred to a genetics centre for information and support.

This overview is intended to be a basic description of the condition. It is not intended to replace specialist medical advice. We advise that you discuss your child’s case with a qualified medical professional who will be able to give you more detailed information.


Medical text reviewed December 2012 by Miss Isabelle Russell-Eggitt, Contact a Family Medical Advisory Panel.

Is there support?

There is no support group for Peters anomaly or Peters Plus syndrome in the UK. Families can use Contact’s freephone helpline for advice, information and, where possible, links to other families. To meet other families with disabled children, join Contact’s closed (private) Facebook group.

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